Phenothiazinum
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Phenothiazinum est in chemia compositum organicum formulae S(C6H4)2NH. Nonnulla phenothiazinorum medicamenta antipsychotica ad schizophreniam therapiam nota sunt[1].
Structura chemica
[recensere | fontem recensere]Structura phenothiazini est 10H-di-benzo-[b,e]-1,4-thiazinum.
Medicamenta antipsychotica
[recensere | fontem recensere]Medicamenta antipsychotica cum phenothiazino in greges tres dividuntur: composita aliphatica, piperidina, piperazina.
| Grex | Effectus autonomicus | Exemplum | Sedativum | Reactio adversa |
| Composita aliphatica | ||||
| moderate | Chlorpromazinum | forte | moderate | |
| Promazinum | moderate | moderate | ||
| Triflupromazinum | forte | moderate/forte | ||
| Laevomepromazinum | fortissime | minime | ||
| Piperidina | fuerte | Mesoridazinum | forte | lente |
| Thioridazinum | forte | lente | ||
| Piperazina | lente | Fluphenazinum | lente/moderate | forte |
| Perphenazinum | lente/moderate | forte | ||
| Prochlorperazinum | ||||
| Trifluoperazinum | moderate | forte |
Effectus biologici
[recensere | fontem recensere]
Apud homines et animales phenothiazina effectus phototoxicos perficiunt: Phenothiazinum una cum luce reactionem adversariam cutaneam provocare possunt.
Notae
[recensere | fontem recensere]- ↑ Jaszczyszyn A, Gasiorowski1 K, Swiatek P, Malinka W, Cieslik-Boczula K, Petrus J, Czarnik-Matusewicz B (2012). "Chemical structure of phenothiazines and their biological activity". Pharmacol Rep 64: 16-23