User talk:KC Panchal

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This is an old revision of this page, as edited by KC Panchal (talk | contribs) at 06:52, 7 May 2008 (→‎Reply to "third" look by Chzz). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

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Hello KC Panchal! Welcome to Wikipedia! Thank you for your contributions. If you decide that you need help, check out Getting Help below, ask me on my talk page, or place {{helpme}} on your talk page and ask your question there. Please remember to sign your name on talk pages by clicking or using four tildes (~~~~); this will automatically produce your name and the date. Finally, please do your best to always fill in the edit summary field. Below are some useful links to facilitate your involvement. Happy editing! Nick—Contact/Contribs 07:13, 4 February 2007 (UTC)[reply]
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Thermodynamic feasibility of converting creatine to phosphocreatine

I got this doubt reading the 25th edition Harper's Biochemistry (the latest is the 26th edition), which I couldn't get resolved even after searching on the internet including Wikipedia. There is a mitochondrial creatine kinase (miCK) present between the inner & outer mitochondrial membranes, which phosphorylates creatine to phosphocreatine at the cost of an ATP molecule (ATP-->ADP), which is exported out the mitochondrion through the pore protein 'P' (pages 147-148). What is the need for such an enzyme if any way cytosolic creatine kinase can carry out the same reaction? My guess, is that it must be faster to transport phosphocreatine out of the mitochondrion than ATP, but I do not know for sure (as such a thing is not WRITTEN in the text); then, once in the cytosol, the phosphocreatine must be getting converted back to creatine, phosphorylating ADP to ATP in the process. But, an even bigger doubt is how id the reaction creatine-->phosphocreatine (requiring 43.1 kJ/mol) thermodynamically feasible if ATP-->ADP releases only 30.5 kJ/mol (page 126; table 12-1)? Looking forward to replies--answers/guesses/just about anything. KC Panchal 10:16, 4 February 2007 (UTC)[reply]

I'm afraid I don't have an answer for your question, but i'd like to direct you to the science reference desk and request that you ask the people there, they're more likely to have an answer than the people who stumble upon your talk page (like myself!). Regards, CycloneNimrodTalk? 22:53, 29 April 2008 (UTC)[reply]

Edit summary

Thanks for leaving an edit summary with practically all your edits. However, there is not normally a need to put ~~~~ in the edit summary, as the Wiki will remember that it was you who made the contribution anyway. Given your interest in medical matters, have you considered joining WP:MED, our medical contributors panel? JFW | T@lk 17:17, 13 April 2008 (UTC)[reply]

Thanks for your kind message. WPMED is open to any contributor regardless of qualifications (many members are medical students). Let me know if you need a hand at any time. JFW | T@lk 11:13, 29 April 2008 (UTC)[reply]
Polyclonal response looks good. I'll review it properly when I have the time. To create a link to subsections, use the "#" (hash) symbol. To link to "See also" in polyclonal response type [[polyclonal response#See also]]. You may want to pipe the link to avoid the hash displaying: [[polyclonal response#See also|see also]]. Cheers. JFW | T@lk 21:19, 30 April 2008 (UTC)[reply]
My access to research papers is not great either - I have access to a couple of core journals. Generally, a general textbook is fine as a source. JFW | T@lk 21:25, 30 April 2008 (UTC)[reply]

Welcome!

Just thought i'd offer you an additional welcome to Wikipedia and to the world of encyclopaedic medicine ;) Good luck and happy editing! Regards, CycloneNimrodTalk? 22:50, 29 April 2008 (UTC)[reply]


Thanks for uploading Image:Schematic diagram depicting polyclonal response by B lymphocytes.JPG. The image has been identified as not specifying the copyright status of the image, which is required by Wikipedia's policy on images. Even if you created the image yourself, you still need to release it so Wikipedia can use it. If you don't indicate the copyright status of the image on the image's description page, using an appropriate copyright tag, it may be deleted some time in the next seven days. If you made this image yourself, you can use copyright tags like {{PD-self}} (to release all rights), {{self|CC-by-sa-3.0|GFDL}} (to require that you be credited), or any tag here - just go to the image, click edit, and add one of those. If you have uploaded other images, please verify that you have provided copyright information for them as well.

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This is an automated notice by STBotI. For assistance on the image use policy, see Wikipedia:Media copyright questions. NOTE: once you correct this, please remove the tag from the image's page. STBotI (talk) 11:53, 30 April 2008 (UTC)[reply]


Thanks for uploading Image:Schematic diagram showing polyclonal response by B lymphocytes.JPG. The image has been identified as not specifying the copyright status of the image, which is required by Wikipedia's policy on images. Even if you created the image yourself, you still need to release it so Wikipedia can use it. If you don't indicate the copyright status of the image on the image's description page, using an appropriate copyright tag, it may be deleted some time in the next seven days. If you made this image yourself, you can use copyright tags like {{PD-self}} (to release all rights), {{self|CC-by-sa-3.0|GFDL}} (to require that you be credited), or any tag here - just go to the image, click edit, and add one of those. If you have uploaded other images, please verify that you have provided copyright information for them as well.

For more information on using images, see the following pages:

This is an automated notice by STBotI. For assistance on the image use policy, see Wikipedia:Media copyright questions. NOTE: once you correct this, please remove the tag from the image's page. STBotI (talk) 07:08, 1 May 2008 (UTC)[reply]

RE: Polyclonal response

You're very welcome! After reviewing your reply I see your point that there is a lack of information that could be placed in an infobox, so yes, withdraw that point! ;)

I see you added polyclonal response to the immunology list, thanks for that. I conducted a minor edit to fix a minor error.

As per Significance, include the uncited claims anyway but place a Citation Needed notice next to it by using the fact template. This can be replaced when sufficient evidence is found. Don't worry to much about being repetitive, others can fix that for you.

Happy editing! Regards, CycloneNimrodTalk? 15:06, 4 May 2008 (UTC)[reply]

Clone

Before you create an article, it's better if you hit the search button. I redirected it to a better one. Dekisugi (talk) 15:34, 4 May 2008 (UTC)[reply]

Please do click Clone (cell biology) and review the redir now. Dekisugi (talk) 15:48, 4 May 2008 (UTC)[reply]

Hi back,

Just had a quick look at your reply...sounds good.

I will look at the article again ASAP - should be within 24 hours.

Chzz (talk) 14:46, 6 May 2008 (UTC)[reply]

Update: have just pasted further comments

Chzz (talk) 18:13, 6 May 2008 (UTC)[reply]

GA review

Just a quick note: Yes, you can nominate "your own" articles for GA status. However, I wouldn't do that just yet with Polyclonal response. We're making good progress with including information that's intelligible to non-scientists, and we need to continue that effort. It would also be worth reviewing the Wikipedia:Good article criteria in advance. Once you've dealt with the specific issues on the talk page, you can use the criteria as a sort of checklist. For example, compliance with six named sections of the Manual of Style is required, and we can take them in turn: Is the introduction compliant? Does the layout follow the usual system? (etc.). Once everyone agrees that we're in good shape (and fixes whatever needs fixing), then one of us should nominate it for GA.

Based on my recent experience, the GA reviewers should be assumed to know absolutely nothing about the general field, much less the specific topic, and to apply rather more stringent requirements than the criteria actually state. Consequently, I think we want the article to be in very good order before nominating it. WhatamIdoing (talk) 21:34, 6 May 2008 (UTC)[reply]

Thanks for the guidance

I don't mind trying making the article worthy of being understood by those with no prior understanding of the topic. What other specific deficiencies do you see apart from the fact that the article does not have six named sections? Ok. Well, I have already nominated the article. Do you suggest taking the nomination back? On the latest front, am uploading another image for linear epitopes.

Please do make frequent "rounds" of this article. You have been quite supportive. Thanks again.

How many reviewers can be expected to give their vote? Are they voluntary users or somehow nominated users? In what kind of time frame is the decision reached?

Regards.

Ketan Panchal, MBBS (talk) 23:26, 6 May 2008 (UTC)[reply]

I'm afraid I haven't been quite clear: There are nineteen sections of requirements in the Manual of Style. A Good Article only has to comply with the rules in six of them (plus anything that could be called "spelling and grammar"). A Featured Article must comply with all 19 sections.
As for what to do: Good Article Nominations can be put on hold, if you want, but it often takes a week or more for them to bubble up to the top, so there's probably plenty of time to think about it. And if they turn us down -- well, we fix the identified problems and nominate it again.
I'm going to be off-wiki for most of the next ~18 hours, but your talk page and the article are on my watchlist, so I'll be back! Thanks for all of your intensive work. (I love the new "tumbled about" version of the epitopes.) WhatamIdoing (talk) 00:35, 7 May 2008 (UTC)[reply]

Re. [[polyclonal response]

  • The image is now much clearer, well done
  • I'm choosing to remain anonymous
  • Re. GA - I suspect the comments by WhatamIdoing above are quite apposite. I thought it would be difficult for such a technical article to get a GA. Difficult, certainly not impossible, and the very best of luck to you with it!
  • Re. GA procedure, study [WP:RGA], specifically "there are no committees, no requirements (beyond a username) to be a reviewer, and no requirements for multiple votes or consensus"
  • I do think that quite a bit of a rewrite would be required, the specific problem area being this part of [WP:WIAGA];
    1. (b) it complies with the manual of style guidelines for lead sections, layout, jargon, words to avoid, fiction, and list incorporation.[1]

...particularly in regard to jargon words. The target audience has to include the 'man on the street' (like myself),as well as experts in the field. I firmly believe that ANY subject, no matter how complex, CAN be made both interesting, accurate and clear.

Thoughts?

Chzz (talk) 00:16, 7 May 2008 (UTC)[reply]

Reply to "third" look by Chzz

Hello!

Thanks for your comment on the image. I almost redid it, and somehow took much longer than I'd thought. I'm sorry I asked you something personal. Or course, you have all the liberty to stay anonymous. Hope the question didn't offend you. I didn't get you--does the article comply or not comply with the above areas (lead, layout, 'words to avoid' and jargon) according to you?

I'm including here a pertinent part of my reply to whatamIdoing:

"But, are the criteria and standards required for a 'good article' the same as a featured article? I don't believe it would be easy for a topic technically so complex to be of much interest to the common person.
Apparently, the greatest hurdle seems to be the jargon (or parlance) being employed. I don't mind at all trying to explain every term in the article, but that would make it very long. Can I attempt that?"

So, I pose the same doubt before you--do I try to explain all the terms in the article, which no doubt, will greatly expand the article, making it very lengthy.

I have another request, do you mind going through another article that I started--clone (cell biology). But, I can assure you right at the outset that you're going to "hate" the picture used!

Thanks for all the support.

Ketan Panchal, MBBS (talk) 06:50, 7 May 2008 (UTC)[reply]

Your science ref desk question

Our docs are very busy and hard to come by. I've had pretty much the same experience. http://en.wikipedia.org/wiki/Wikipedia_talk:WikiProject_Medicine may give you a bit more success, but by and large your best bet is look up someone that specializes in that area here http://en.wikipedia.org/wiki/Wikipedia:WikiProject_Medicine/Participants and leave your question on their talk page. I didn't want to put that on the ref desk to keep every yo-yo in creation from bothering people. Your question seemed legit. Good luck.  :-) Disclaimer: This is not medical advice ;-) 71.236.23.111 (talk) 06:36, 7 May 2008 (UTC)[reply]

  1. ^ It is strongly recommended that the Manual of Style is broadly followed, but this is not required for good articles.
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