Random coil
In biochemistry, a protein or a segment of a protein that completely lacks secondary_structure is a random coil. In random coil, the only fixed relationship between amino acids is that between adjacent residues through the peptide bond. As a result, random coil can be detected from the absence of signals in a multidimensional nuclear magnetic resonance experiment that depend on particular peptide-peptide interactions. Random coil is also easily distinguished by circular dichroism. Denaturing reduces a protein entirely to random coil.