Indatraline

From Wikipedia, the free encyclopedia

This is an old revision of this page, as edited by Woood (talk | contribs) at 01:34, 20 November 2007 (block the action of methamphetamine). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Jump to navigation Jump to search
Indatraline
Identifiers
  • (1R,3S)-3-(3,4-dichlorophenyl)-N-methyl-2,3-dihydro-1H-inden-1-amine
CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC16H15Cl2N
Molar mass292.202 g/mol g·mol−1

Indatraline, also known as Lu 19-005, is a nonselective monoamine reuptake inhibitor that has been shown to block the reuptake of dopamine, norepinephrine, and serotonin with effects similar to those of cocaine. However, the effects have been shown to have slower onset and longer duration than cocaine, suggesting that the compound may, along with similar compounds, be used for treatment of cocaine abuse.[1] Research has also suggested that indatraline can be used to block the action of methamphetamine.<ref>Rothman, B. R. eta al, "Neurochemical Neutralization of Methamphetamine With High-Affinity Nonselective Inhibitors of Biogenic Amine Transporters: A Pharmacological Strategy for Treating Stimulant Abuse." Synapse (2000) 35:222-227.[2]

For a more detailed discussion of indatraline pharmacology, see Indatraline pharmacology


References

  1. ^ Negus SS, Brandt MR, Mello NK. "Effects of the long-acting monoamine reuptake inhibitor indatraline on cocaine self-administration in rhesus monkeys." J Pharmacol Exp Ther (1999) 291(1):60-9.[1]
Retrieved from "https://en.wikipedia.org/w/index.php?title=Indatraline&oldid=172610655"