North by Northwest
North By Northwest is a 1959 film about a businessman who is mistaken for a government agent and is being pursued by spies he's unfamiliar with and who want to kill him. The businessman, played by Cary Grant, is framed for murder and involves himself in the conspiracy to try to clear his name. The film has several plot twists and a sly sense of humor, as well as the famous scenes in which a character is chased by a crop duster and, later, two characters are climbing over the faces on Mount Rushmore to escape the spies.
The film was directed by Alfred Hitchcock and stars Grant, Eva Marie Saint, James Mason, Leo G. Carroll, and Martin Landau. It is #40 on American Film Institute's 100 Years, 100 Movies, #4 on its 100 Years, 100 Thrills, and is consistently in the top 25 on the Internet Movie Database's Top 250.